Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction
E Marzetti, CS Carter, SE Wohlgemuth, HA Lees… - Mechanisms of ageing …, 2009 - Elsevier
TNF-α-mediated apoptosis is enhanced in aged rodent muscles, suggesting that this
pathway may be involved in sarcopenia. Interleukin-15 (IL-15), a muscle-derived anabolic
cytokine, mitigates muscle wasting and apoptosis in cachectic rats. This effect is thought to
occur through inhibition of TNF-α-triggered apoptosis. We investigated IL-15 signaling and
the TNF-α-mediated pathway of apoptosis in the gastrocnemius muscle of
Fischer344xBrown Norway rats across the ages of 8, 18, 29 and 37 months, in relation to life …
pathway may be involved in sarcopenia. Interleukin-15 (IL-15), a muscle-derived anabolic
cytokine, mitigates muscle wasting and apoptosis in cachectic rats. This effect is thought to
occur through inhibition of TNF-α-triggered apoptosis. We investigated IL-15 signaling and
the TNF-α-mediated pathway of apoptosis in the gastrocnemius muscle of
Fischer344xBrown Norway rats across the ages of 8, 18, 29 and 37 months, in relation to life …