IL-15/IL-15 receptor biology: a guided tour through an expanding universe
V Budagian, E Bulanova, R Paus… - Cytokine & growth factor …, 2006 - Elsevier
The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and
activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-
15 affects a wider range of target cell populations and utilizes different mechanisms of
signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the
functional properties on cells besides T lymphocytes and NK cells. These are discussed in
the context of their potential clinical and therapeutic relevance.
activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-
15 affects a wider range of target cell populations and utilizes different mechanisms of
signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the
functional properties on cells besides T lymphocytes and NK cells. These are discussed in
the context of their potential clinical and therapeutic relevance.