[HTML][HTML] Intracellular interaction of interleukin-15 with its receptor α during production leads to mutual stabilization and increased bioactivity
C Bergamaschi, M Rosati, R Jalah, A Valentin… - Journal of Biological …, 2008 - ASBMB
We show that co-expression of interleukin 15 (IL-15) and IL-15 receptor α (IL-15Rα) in the
same cell allows for the intracellular interaction of the two proteins early after translation,
resulting in increased stability and secretion of both molecules as a complex. In the absence
of co-expressed IL-15Rα, a large portion of the produced IL-15 is rapidly degraded
immediately after synthesis. Co-injection into mice of IL-15 and IL-15Rα expression
plasmids led to significantly increased levels of the cytokine in serum as well as increased …
same cell allows for the intracellular interaction of the two proteins early after translation,
resulting in increased stability and secretion of both molecules as a complex. In the absence
of co-expressed IL-15Rα, a large portion of the produced IL-15 is rapidly degraded
immediately after synthesis. Co-injection into mice of IL-15 and IL-15Rα expression
plasmids led to significantly increased levels of the cytokine in serum as well as increased …