BRCA1 and its toolbox for the maintenance of genome integrity

MSY Huen, SMH Sy, J Chen - Nature reviews Molecular cell biology, 2010 - nature.com
MSY Huen, SMH Sy, J Chen
Nature reviews Molecular cell biology, 2010nature.com
The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the
maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression
function primarily through its involvement in cell cycle checkpoint control and DNA damage
repair. In addition, recent proteomic and genetic studies have revealed the presence of
distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to
DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its …
Abstract
The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response.
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