[PDF][PDF] Association of steroid and xenobiotic receptor (SXR) and multidrug resistance 1 (MDR1) gene expression with survival among patients with invasive bladder …

J Rioja, E Bandrés, D Rosell Costa… - … -British Journal of …, 2011 - researchgate.net
J Rioja, E Bandrés, D Rosell Costa, A Rincón, I López, JJ Zudaire Bergera…
BJU International-British Journal of Urology, 2011researchgate.net
RESULTS• Patients were followed for a mean of 29 months; 31 patients (46%) had
progression.• In univariate analysis, significant predictors of overall survival (OS) were
pathological stage, lymph node (LN) status, histological grade, vascular-lymphatic invasion,
and SXR expression.• In multivariate analysis, independent predictors of OS were LN status
(odds ratio [OR], 2.96; P= 0.034), vascular-lymphatic invasion (OR, 2.50; P= 0.029), and SXR
expression (OR, 1.05, P= 0.03).• Among the 51 patients with negative LNs (pN0), univariate …
RESULTS
• Patients were followed for a mean of 29 months; 31 patients (46%) had progression.
• In univariate analysis, significant predictors of overall survival (OS) were pathological stage, lymph node (LN) status, histological grade, vascular-lymphatic invasion, and SXR expression.• In multivariate analysis, independent predictors of OS were LN status (odds ratio [OR], 2.96; P= 0.034), vascular-lymphatic invasion (OR, 2.50; P= 0.029), and SXR expression (OR, 1.05, P= 0.03).• Among the 51 patients with negative LNs (pN0), univariate predictors of OS were SXR expression, MDR1 expression, and pathological stage. In multivariate analysis, SXR expression (OR, 1.06; P= 0.01) and MDR1 expression (OR, 3.27; P= 0.03) were independently associated with survival.
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