[HTML][HTML] Pregnane X receptor PXR activates the GADD45β gene, eliciting the p38 MAPK signal and cell migration

S Kodama, M Negishi - Journal of biological chemistry, 2011 - ASBMB
Pregnane X receptor (PXR) was originally characterized as a transcription factor that
induces hepatic drug metabolism by activating cytochrome P450 genes. Here we have now
demonstrated a novel function of PXR, that of eliciting p38 mitogen-activated protein kinase
(MAPK) phosphorylation for cell migration. Upon xenobiotic activation of ectopic human
PXR, human hepatocellular carcinoma HepG2 cells were found to exhibit increased
phosphorylation of p38 MAPK and to subsequently change morphology and migrate. p38 …