Angiotensin II-induced changes of calcium sparks and ionic currents in human atrial myocytes: potential role for early remodeling in atrial fibrillation
N Gassanov, MC Brandt, G Michels, M Lindner, F Er… - Cell calcium, 2006 - Elsevier
AIMS: Atrial angiotensin II (ANG II) levels have been shown to be increased in atrial
fibrillation (AF). The purpose of the study was to evaluate a potential role of ANG II in the
early remodeling and susceptibility to chronicization of AF. METHODS AND RESULTS:
Isolated human atrial myocytes were incubated in ANG II and/or angiotensin type 1 receptor
blocker candesartan. ANG II markedly increased the frequency of spontaneous Ca2+
sparks, spark full duration, time to peak Ca2+ fluorescence and decay time measured by …
fibrillation (AF). The purpose of the study was to evaluate a potential role of ANG II in the
early remodeling and susceptibility to chronicization of AF. METHODS AND RESULTS:
Isolated human atrial myocytes were incubated in ANG II and/or angiotensin type 1 receptor
blocker candesartan. ANG II markedly increased the frequency of spontaneous Ca2+
sparks, spark full duration, time to peak Ca2+ fluorescence and decay time measured by …