Autonomic dysfunction in PD: a window to early detection?
DS Goldstein, LT Sewell, Y Sharabi - Journal of the neurological sciences, 2011 - Elsevier
It has been suggested that autonomic dysfunction constitutes a biomarker for early detection
of the disease process in Parkinson disease (PD). Recent findings based on cardiac
sympathetic and striatal dopaminergic imaging in the same patients indicate that this view is
overly simple. Although evidence of cardiac sympathetic denervation is associated with
other non-motor manifestations such as anosmia, REM behavior disorder, dementia,
baroreflex failure, and orthostatic hypotension (OH), across individual patients the severities …
of the disease process in Parkinson disease (PD). Recent findings based on cardiac
sympathetic and striatal dopaminergic imaging in the same patients indicate that this view is
overly simple. Although evidence of cardiac sympathetic denervation is associated with
other non-motor manifestations such as anosmia, REM behavior disorder, dementia,
baroreflex failure, and orthostatic hypotension (OH), across individual patients the severities …