[HTML][HTML] The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent …
A Bhattacharyya, UYS Ear, BH Koller… - Journal of Biological …, 2000 - ASBMB
Mutations in breast cancer tumor susceptibility genes, BRCA1 and BRCA2, predispose
women to early onset breast cancer and other malignancies. The Brca genes are involved in
multiple cellular processes in response to DNA damage including checkpoint activation,
gene transcription, and DNA repair. Biochemical interaction with the recombinational repair
protein Rad51 (Scully, R., Chen, J., Ochs, RL, Keegan, K., Hoekstra, M., Feunteun, J., and
Livingston, DM (1997) Cell 90, 425–435), as well as genetic evidence (Moynahan, ME …
women to early onset breast cancer and other malignancies. The Brca genes are involved in
multiple cellular processes in response to DNA damage including checkpoint activation,
gene transcription, and DNA repair. Biochemical interaction with the recombinational repair
protein Rad51 (Scully, R., Chen, J., Ochs, RL, Keegan, K., Hoekstra, M., Feunteun, J., and
Livingston, DM (1997) Cell 90, 425–435), as well as genetic evidence (Moynahan, ME …