Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination model
SW Hayward, PC Haughney, MA Rosen, KM Greulich… - Differentiation, 1998 - Elsevier
Tissue recombinants composed of adult human prostatic epithelium (hPrE) and rat
urogenital sinus mesenchyme (rUGM) were grafted beneath the renal capsule of athymic
rodent hosts. The pseudostratified human epithelium initially became multilayered, solid
epithelial cords emerged, grew into the surrounding mesenchyme and canalized to
regenerate a pseudostratified epithelium. Basal cells expressed cytokeratins 5 and 14, while
luminal cells expressed cytokeratins 8 and 18, prostate specific antigen and prostatic acid …
urogenital sinus mesenchyme (rUGM) were grafted beneath the renal capsule of athymic
rodent hosts. The pseudostratified human epithelium initially became multilayered, solid
epithelial cords emerged, grew into the surrounding mesenchyme and canalized to
regenerate a pseudostratified epithelium. Basal cells expressed cytokeratins 5 and 14, while
luminal cells expressed cytokeratins 8 and 18, prostate specific antigen and prostatic acid …