Cell cycle regulation: repair and regeneration in acute renal failure
PM Price, J Megyesi, RL Safirstein - Seminars in nephrology, 2003 - Elsevier
Research into mechanisms of acute renal failure has begun to reveal molecular targets for
possible therapeutic intervention. Much useful knowledge into the causes and prevention of
this syndrome has been gained by the study of animal models. Most recently, investigation
of the effects on acute renal failure of selected gene knock-outs in mice has contributed to
our recognition of many previously unappreciated molecular pathways. Particularly,
experiments have revealed the protective nature of 2 highly induced genes whose functions …
possible therapeutic intervention. Much useful knowledge into the causes and prevention of
this syndrome has been gained by the study of animal models. Most recently, investigation
of the effects on acute renal failure of selected gene knock-outs in mice has contributed to
our recognition of many previously unappreciated molecular pathways. Particularly,
experiments have revealed the protective nature of 2 highly induced genes whose functions …