Glial conversion of SVZ-derived committed neuronal precursors after ectopic grafting into the adult brain
R Seidenfaden, A Desoeuvre, A Bosio, I Virard… - Molecular and cellular …, 2006 - Elsevier
In the adult mouse forebrain, large numbers of neuronal precursors, destined to become
GABA-and dopamine-producing interneurons of the olfactory bulb (OB), are generated in the
subventricular zone (SVZ). Although this neurogenic system represents a potential reservoir
of stem and progenitor cells for brain repair approaches, information about the survival and
differentiation of SVZ-derived cells in ectopic brain regions is still fragmentary. We show
here that ectopic grafting of SVZ tissue gave rise to two morphologically distinguishable cell …
GABA-and dopamine-producing interneurons of the olfactory bulb (OB), are generated in the
subventricular zone (SVZ). Although this neurogenic system represents a potential reservoir
of stem and progenitor cells for brain repair approaches, information about the survival and
differentiation of SVZ-derived cells in ectopic brain regions is still fragmentary. We show
here that ectopic grafting of SVZ tissue gave rise to two morphologically distinguishable cell …