Enhanced interferon-αβ (IFN-αβ) and defective IFN-γ production in chronic graft versus host disease: A potential mechanism for immunosuppression
MG Cleveland, RG Lane, GR Klimpel - Cellular immunology, 1987 - Elsevier
Immunosuppression is a well-characterized consequence of chronic graft-versus-host
disease (GVHD). We have previously shown that interferon (IFN) is produced in high levels
during acute GVHD. Our objective in this study was to determine if IFN, as a cytokine with
known immunosuppressive qualities, could be detected in mice experiencing chronic GVHD-
induced immunosuppression. Two different experimental models were used to induce
chronic GVHD. The first model involved the injection of parental strain spleen cells into adult …
disease (GVHD). We have previously shown that interferon (IFN) is produced in high levels
during acute GVHD. Our objective in this study was to determine if IFN, as a cytokine with
known immunosuppressive qualities, could be detected in mice experiencing chronic GVHD-
induced immunosuppression. Two different experimental models were used to induce
chronic GVHD. The first model involved the injection of parental strain spleen cells into adult …