Fibroblast clones from patients with Hutchinson–Gilford progeria can senesce despite the presence of telomerase
CV Wallis, AN Sheerin, MHL Green, CJ Jones… - Experimental …, 2004 - Elsevier
Hutchinson–Gilford progeria (HGP) is a genetic disorder in which individuals prematurely
display features of ageing. Mutations in LMNA (lamin A) have recently been shown to
underlie HGP, although how such mutations lead to the complex phenotype seen in the
disease remains unclear. HGP is often associated with the premature replicative
senescence of dermal fibroblasts. Normally dermal fibroblast senescence is initiated by
erosion of chromosomal ends (telomeres) resulting from sustained cell division. Since …
display features of ageing. Mutations in LMNA (lamin A) have recently been shown to
underlie HGP, although how such mutations lead to the complex phenotype seen in the
disease remains unclear. HGP is often associated with the premature replicative
senescence of dermal fibroblasts. Normally dermal fibroblast senescence is initiated by
erosion of chromosomal ends (telomeres) resulting from sustained cell division. Since …