Apolipoprotein E (apoE) and its receptor, very low density lipoprotein receptor (VLDLR), are
involved in fat accumulation in adipocytes. Here, we investigated the effect of a peroxisome
proliferator-activated receptor (PPAR) γ agonist, rosiglitazone, on regulation of VLDLR
expression both in white adipose tissue (WAT) of obese mice and in cultured adipocytes.
Furthermore, to determine whether rosiglitazone directly regulates transcription of the
VLDLR gene, we carried out luciferase assay with a reporter gene containing mouse VLDLR …