Regulation of ApoE receptor proteolysis by ligand binding
Two brain receptors for apolipoprotein E (apoE), the apoE receptor 2 (apoEr2) and the very
low density lipoprotein receptor (VLDLr), are important in neuronal migration during
development. Using a series of tagged constructs, we found that these two receptors
undergo extracellular cleavages to release secreted forms of the receptors and
intramembranous cleavages to degrade the C-terminal fragments. Release of the
extracellular domains was blocked by an inhibitor of metalloproteinases and increased by …
low density lipoprotein receptor (VLDLr), are important in neuronal migration during
development. Using a series of tagged constructs, we found that these two receptors
undergo extracellular cleavages to release secreted forms of the receptors and
intramembranous cleavages to degrade the C-terminal fragments. Release of the
extracellular domains was blocked by an inhibitor of metalloproteinases and increased by …