[HTML][HTML] Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high …

J Watanabe, V Grijalva, S Hama, K Barbour… - Journal of Biological …, 2009 - ASBMB
Hemoglobin (Hb) uniquely associates with proinflammatory HDL in atherogenic mice and
coronary heart disease (CHD) patients. In this paper, we report that Hb and its scavenger
proteins, haptoglobin (Hp) and hemopexin (Hx) are significantly increased in apoA-1-
containing particles of HDL both in mouse models of hyperlipidemia and in CHD patients,
when compared with wild type mice and healthy donors, respectively. We further
demonstrate that the association of Hb, Hp, and Hx proteins with HDL positively correlates …