[HTML][HTML] Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and …
LYW Bourguignon, K Peyrollier, W Xia… - Journal of Biological …, 2008 - ASBMB
Hyaluronan (HA) is a major glycosaminoglycan in the extracellular matrix whose expression
is tightly linked to multidrug resistance and tumor progression. In this study we investigated
HA-induced interaction between CD44 (a HA receptor) and Nanog (an embryonic stem cell
transcription factor) in both human breast tumor cells (MCF-7 cells) and human ovarian
tumor cells (SK-OV-3. ipl cells). Using a specific primer pair to amplify Nanog by reverse
transcriptase-PCR, we detected the expression of Nanog transcript in both tumor cell lines …
is tightly linked to multidrug resistance and tumor progression. In this study we investigated
HA-induced interaction between CD44 (a HA receptor) and Nanog (an embryonic stem cell
transcription factor) in both human breast tumor cells (MCF-7 cells) and human ovarian
tumor cells (SK-OV-3. ipl cells). Using a specific primer pair to amplify Nanog by reverse
transcriptase-PCR, we detected the expression of Nanog transcript in both tumor cell lines …