[HTML][HTML] Terminal N-linked galactose is the primary receptor for adeno-associated virus 9
S Shen, KD Bryant, SM Brown, SH Randell… - Journal of Biological …, 2011 - ASBMB
Sialylated glycans serve as cell surface attachment factors for a broad range of pathogens.
We report an atypical example, where desialylation increases cell surface binding and
infectivity of adeno-associated virus (AAV) serotype 9, a human parvovirus isolate.
Enzymatic removal of sialic acid, but not heparan sulfate or chondroitin sulfate, increased
AAV9 transduction regardless of cell type. Viral binding and transduction assays on mutant
Chinese hamster ovary (CHO) cell lines defective in various stages of glycan chain …
We report an atypical example, where desialylation increases cell surface binding and
infectivity of adeno-associated virus (AAV) serotype 9, a human parvovirus isolate.
Enzymatic removal of sialic acid, but not heparan sulfate or chondroitin sulfate, increased
AAV9 transduction regardless of cell type. Viral binding and transduction assays on mutant
Chinese hamster ovary (CHO) cell lines defective in various stages of glycan chain …