Comp–angiopoietin-1 ameliorates renal fibrosis in a unilateral ureteral obstruction model
W Kim, SO Moon, SY Lee, KY Jang… - Journal of the …, 2006 - journals.lww.com
Injury to the renal microvasculature may be a major factor in the progression of renal
disease; therefore, protection of endothelial cells (EC) in renal vasculature may have a
therapeutic role in renal fibrosis. Recently, a soluble, stable, and potent angiopoietin-1
(Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1, was developed. The
contribution of COMP-Ang1 in renal interstitial fibrosis, however, remains to be clarified. This
study investigated the effects of COMP-Ang1 on peritubular capillary EC in the renal cortex …
disease; therefore, protection of endothelial cells (EC) in renal vasculature may have a
therapeutic role in renal fibrosis. Recently, a soluble, stable, and potent angiopoietin-1
(Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1, was developed. The
contribution of COMP-Ang1 in renal interstitial fibrosis, however, remains to be clarified. This
study investigated the effects of COMP-Ang1 on peritubular capillary EC in the renal cortex …
