[HTML][HTML] Highly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase
K Wakasugi, P Schimmel - Journal of Biological Chemistry, 1999 - ASBMB
While native human tyrosyl-tRNA synthetase (TyrRS) is inactive as a cell-signaling
molecule, it can be split into two distinct cytokines. The enzyme is secreted under apoptotic
conditions in culture where it is cleaved into an N-terminal fragment that harbors the catalytic
site and into a C-domain fragment found only in the mammalian enzymes. The N-terminal
fragment is an interleukin-8 (IL-8)-like cytokine, whereas the released C-domain is an
endothelial-monocyte-activating polypeptide II (EMAP II)-like cytokine. Although the IL-8-like …
molecule, it can be split into two distinct cytokines. The enzyme is secreted under apoptotic
conditions in culture where it is cleaved into an N-terminal fragment that harbors the catalytic
site and into a C-domain fragment found only in the mammalian enzymes. The N-terminal
fragment is an interleukin-8 (IL-8)-like cytokine, whereas the released C-domain is an
endothelial-monocyte-activating polypeptide II (EMAP II)-like cytokine. Although the IL-8-like …