[HTML][HTML] The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7
HA Behrensdorf, M Van De Craen, UE Knies… - FEBS letters, 2000 - Elsevier
HA Behrensdorf, M Van De Craen, UE Knies, P Vandenabeele, M Clauss
FEBS letters, 2000•ElsevierEndothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a
chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage
of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP
II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the
sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and
release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of …
chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage
of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP
II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the
sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and
release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of …
Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation.
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