Association of leptin receptor (OB-Rb), NPY and GLP-1 gene expression in the ovine and murine brainstem

JG Mercer, KM Moar, PA Findlay, N Hoggard… - Regulatory peptides, 1998 - Elsevier
Appetite-related neuropeptide systems have not been studied extensively in the ruminant,
although there have been a number of recent studies of the hypothalamus. Since some
leptin signaling is integrated in the rodent brainstem, and leptin modulates neuropeptidergic
activity, we now describe leptin receptor (long splice variant, OB-Rb), neuropeptide Y (NPY)
and glucagon-like peptide-1 (GLP-1) gene expression in the ovine brainstem. Leptin
receptor mRNA was localized to the spinal trigeminal tract and nucleus, nucleus of the …