Insufficient sleep undermines dietary efforts to reduce adiposity
AV Nedeltcheva, JM Kilkus, J Imperial… - Annals of internal …, 2010 - acpjournals.org
AV Nedeltcheva, JM Kilkus, J Imperial, DA Schoeller, PD Penev
Annals of internal medicine, 2010•acpjournals.orgBackground: Sleep loss can modify energy intake and expenditure. Objective: To determine
whether sleep restriction attenuates the effect of a reduced-calorie diet on excess adiposity.
Design: Randomized, 2-period, 2-condition crossover study. Setting: University clinical
research center and sleep laboratory. Patients: 10 overweight nonsmoking adults (3 women
and 7 men) with a mean age of 41 years (SD, 5) and a mean body mass index of 27.4 kg/m2
(SD, 2.0). Intervention: 14 days of moderate caloric restriction with 8.5 or 5.5 hours of …
whether sleep restriction attenuates the effect of a reduced-calorie diet on excess adiposity.
Design: Randomized, 2-period, 2-condition crossover study. Setting: University clinical
research center and sleep laboratory. Patients: 10 overweight nonsmoking adults (3 women
and 7 men) with a mean age of 41 years (SD, 5) and a mean body mass index of 27.4 kg/m2
(SD, 2.0). Intervention: 14 days of moderate caloric restriction with 8.5 or 5.5 hours of …
Background
Sleep loss can modify energy intake and expenditure.
Objective
To determine whether sleep restriction attenuates the effect of a reduced-calorie diet on excess adiposity.
Design
Randomized, 2-period, 2-condition crossover study.
Setting
University clinical research center and sleep laboratory.
Patients
10 overweight nonsmoking adults (3 women and 7 men) with a mean age of 41 years (SD, 5) and a mean body mass index of 27.4 kg/m2 (SD, 2.0).
Intervention
14 days of moderate caloric restriction with 8.5 or 5.5 hours of nighttime sleep opportunity.
Measurements
The primary measure was loss of fat and fat-free body mass. Secondary measures were changes in substrate utilization, energy expenditure, hunger, and 24-hour metabolic hormone concentrations.
Results
Sleep curtailment decreased the proportion of weight lost as fat by 55% (1.4 vs. 0.6 kg with 8.5 vs. 5.5 hours of sleep opportunity, respectively; P = 0.043) and increased the loss of fat-free body mass by 60% (1.5 vs. 2.4 kg; P = 0.002). This was accompanied by markers of enhanced neuroendocrine adaptation to caloric restriction, increased hunger, and a shift in relative substrate utilization toward oxidation of less fat.
Limitation
The nature of the study limited its duration and sample size.
Conclusion
The amount of human sleep contributes to the maintenance of fat-free body mass at times of decreased energy intake. Lack of sufficient sleep may compromise the efficacy of typical dietary interventions for weight loss and related metabolic risk reduction.
Primary Funding Source
National Institutes of Health.
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