The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
T Sakurai - Nature Reviews Neuroscience, 2007 - nature.com
Nature Reviews Neuroscience, 2007•nature.com
Sleep and wakefulness are regulated to occur at appropriate times that are in accordance
with our internal and external environments. Avoiding danger and finding food, which are life-
essential activities that are regulated by emotion, reward and energy balance, require
vigilance and therefore, by definition, wakefulness. The orexin (hypocretin) system regulates
sleep and wakefulness through interactions with systems that regulate emotion, reward and
energy homeostasis.
with our internal and external environments. Avoiding danger and finding food, which are life-
essential activities that are regulated by emotion, reward and energy balance, require
vigilance and therefore, by definition, wakefulness. The orexin (hypocretin) system regulates
sleep and wakefulness through interactions with systems that regulate emotion, reward and
energy homeostasis.
Abstract
Sleep and wakefulness are regulated to occur at appropriate times that are in accordance with our internal and external environments. Avoiding danger and finding food, which are life-essential activities that are regulated by emotion, reward and energy balance, require vigilance and therefore, by definition, wakefulness. The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis.
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