The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems

EE Abrahamson, RK Leak, RY Moore - Neuroreport, 2001 - journals.lww.com
The suprachiasmatic nucleus (SCN) temporally organizes behavior in part by sustaining
arousal during the wake period of the sleep/wake cycle to consolidate adaptive waking
behavior. In this study, we demonstrate direct projections from the SCN, in both the rat and
the human brains, to perikarya and proximal dendrites of two groups of posterior
hypothalamic neurons with axonal projections that suggest they are important in the
regulation of arousal, one producing hypocretins (HCT) and the other melanin-concentrating …