Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

FW Turek, C Joshu, A Kohsaka, E Lin, G Ivanova… - Science, 2005 - science.org
FW Turek, C Joshu, A Kohsaka, E Lin, G Ivanova, E McDearmon, A Laposky, S Losee-Olson…
Science, 2005science.org
The CLOCK transcription factor is a key component of the molecular circadian clock within
pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that
homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are
hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia,
hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of
transcripts encoding selected hypothalamic peptides associated with energy balance was …
The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice. These results suggest that the circadian clock gene network plays an important role in mammalian energy balance.
AAAS