[HTML][HTML] Inflammation of the hypothalamus leads to defective pancreatic islet function
VC Calegari, AS Torsoni, EC Vanzela… - Journal of Biological …, 2011 - ASBMB
Type 2 diabetes mellitus results from the complex association of insulin resistance and
pancreatic β-cell failure. Obesity is the main risk factor for type 2 diabetes mellitus, and
recent studies have shown that, in diet-induced obesity, the hypothalamus becomes
inflamed and dysfunctional, resulting in the loss of the perfect coupling between caloric
intake and energy expenditure. Because pancreatic β-cell function is, in part, under the
control of the autonomic nervous system, we evaluated the role of hypothalamic …
pancreatic β-cell failure. Obesity is the main risk factor for type 2 diabetes mellitus, and
recent studies have shown that, in diet-induced obesity, the hypothalamus becomes
inflamed and dysfunctional, resulting in the loss of the perfect coupling between caloric
intake and energy expenditure. Because pancreatic β-cell function is, in part, under the
control of the autonomic nervous system, we evaluated the role of hypothalamic …