[HTML][HTML] Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes [S]
S Ranjit, E Boutet, P Gandhi, M Prot, Y Tamori… - Journal of lipid …, 2011 - ASBMB
The lipid droplet-associated fat specific protein 27 (FSP27) suppresses lipolysis and thereby
enhances triglyceride accumulation in adipocytes. We and others have recently found
FSP27 to be a remarkably short-lived protein (half-life, 15 min) due to its rapid ubiquitination
and proteasomal degradation. Thus, we tested the hypothesis that lipolytic agents such as
tumor necrosis factor-α (TNF-α) and isoproterenol modulate FSP27 levels to regulate FFA
release. Consistent with this concept, we showed that the lipolytic actions of TNF-α …
enhances triglyceride accumulation in adipocytes. We and others have recently found
FSP27 to be a remarkably short-lived protein (half-life, 15 min) due to its rapid ubiquitination
and proteasomal degradation. Thus, we tested the hypothesis that lipolytic agents such as
tumor necrosis factor-α (TNF-α) and isoproterenol modulate FSP27 levels to regulate FFA
release. Consistent with this concept, we showed that the lipolytic actions of TNF-α …