[HTML][HTML] Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis
J Kovsan, R Ben-Romano, SC Souza… - Journal of Biological …, 2007 - ASBMB
A decrease in the lipid droplet-associated protein perilipin may constitute a mechanism for
enhanced adipocyte lipolysis under nonstimulated (basal) conditions, and increased basal
lipolysis has been linked to whole body metabolic dysregulation. Here we investigated
whether the lipolytic actions of the human immunodeficiency virus protease inhibitor,
nelfinavir, are mediated by decreased perilipin protein content and studied the mechanisms
by which it occurs. Time course analysis revealed that the decrease in perilipin protein …
enhanced adipocyte lipolysis under nonstimulated (basal) conditions, and increased basal
lipolysis has been linked to whole body metabolic dysregulation. Here we investigated
whether the lipolytic actions of the human immunodeficiency virus protease inhibitor,
nelfinavir, are mediated by decreased perilipin protein content and studied the mechanisms
by which it occurs. Time course analysis revealed that the decrease in perilipin protein …