[HTML][HTML] Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and …

S Miura, JW Gan, J Brzostowski, MJ Parisi… - Journal of Biological …, 2002 - ASBMB
Intracellular neutral lipid storage droplets are essential organelles of eukaryotic cells, yet
little is known about the proteins at their surfaces or about the amino acid sequences that
target proteins to these storage droplets. The mammalian proteins Perilipin, ADRP, and
TIP47 share extensive amino acid sequence similarity, suggesting a common function.
However, while Perilipin and ADRP localize exclusively to neutral lipid storage droplets, an
association of TIP47 with intracellular lipid droplets has been controversial. We now show …