[HTML][HTML] DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity
L Liu, XJ Shi, KG Bharadwaj, S Ikeda… - Journal of biological …, 2009 - ASBMB
Intracellular lipid accumulation in the heart is associated with cardiomyopathy, yet the
precise role of triglyceride (TG) remains unclear. With exercise, wild type hearts develop
physiologic hypertrophy. This was associated with greater TG stores and a marked induction
of the TG-synthesizing enzyme diacylglycerol (DAG) acyltransferase 1 (DGAT1). Transgenic
overexpression of DGAT1 in the heart using the cardiomyocyte-specific α-myosin heavy
chain (MHC) promoter led to approximately a doubling of DGAT activity and TG content and …
precise role of triglyceride (TG) remains unclear. With exercise, wild type hearts develop
physiologic hypertrophy. This was associated with greater TG stores and a marked induction
of the TG-synthesizing enzyme diacylglycerol (DAG) acyltransferase 1 (DGAT1). Transgenic
overexpression of DGAT1 in the heart using the cardiomyocyte-specific α-myosin heavy
chain (MHC) promoter led to approximately a doubling of DGAT activity and TG content and …