[HTML][HTML] Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice [S]
AM Hall, EM Brunt, Z Chen, N Viswakarma… - Journal of lipid …, 2010 - ASBMB
Lipid droplet proteins (LDPs) coat the surface of triglyceride-rich lipid droplets and regulate
their formation and lipolysis. We profiled hepatic LDP expression in fatty liver dystrophic (fld)
mice, a unique model of neonatal hepatic steatosis that predictably resolves between
postnatal day 14 (P14) and P17. Western blotting revealed that perilipin-2/ADRP and
perilipin-5/OXPAT were markedly increased in steatotic fld liver but returned to normal by
P17. However, the changes in perilipin-2 and perilipin-5 protein content in fld mice were …
their formation and lipolysis. We profiled hepatic LDP expression in fatty liver dystrophic (fld)
mice, a unique model of neonatal hepatic steatosis that predictably resolves between
postnatal day 14 (P14) and P17. Western blotting revealed that perilipin-2/ADRP and
perilipin-5/OXPAT were markedly increased in steatotic fld liver but returned to normal by
P17. However, the changes in perilipin-2 and perilipin-5 protein content in fld mice were …