Recent evidence suggests that fatty acids generated from intracellular triacylglycerol (TAG)
hydrolysis may have important roles in intracellular signaling. This study was conducted to
determine if fatty acids liberated from TAG hydrolysis regulate peroxisome proliferator-
activated receptor α (PPARα). Primary rat hepatocyte cultures were treated with
adenoviruses overexpressing adipose differentiation-related protein (ADRP) or adipose
triacylglycerol lipase (ATGL) or treated with short interfering RNA (siRNA) targeted against …