Nck proteins maintain the adult glomerular filtration barrier

N Jones, LA New, MA Fortino, V Eremina… - Journal of the …, 2009 - journals.lww.com
Within the glomerulus, the scaffolding protein nephrin bridges the actin-rich foot processes
that extend from adjacent podocytes to form the slit diaphragm. Mutations affecting a number
of slit diaphragm proteins, including nephrin, cause glomerular disease through
rearrangement of the actin cytoskeleton and disruption of the filtration barrier. We recently
established that the Nck family of Src homology 2 (SH2)/SH3 cytoskeletal adaptor proteins
can mediate nephrin-dependent actin reorganization. Formation of foot processes requires …