Mucosal macrophages and the regulation of immune responses in the intestine
AM Platt, AMI Mowat - Immunology letters, 2008 - Elsevier
The healthy intestinal mucosa is home to one of the largest populations of macrophages
(mϕ) in the body [Lee SH, Starkey PM, Gordon S. Quantitative analysis of total macrophage
content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80. J
Exp Med 1985; 161: 475–89], yet little is known about their function. Resident mϕ in the
large and small intestine are distinct from other mϕ populations in the body, with regards to
both their functional properties and surface phenotype. They respond in an unconventional …
(mϕ) in the body [Lee SH, Starkey PM, Gordon S. Quantitative analysis of total macrophage
content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80. J
Exp Med 1985; 161: 475–89], yet little is known about their function. Resident mϕ in the
large and small intestine are distinct from other mϕ populations in the body, with regards to
both their functional properties and surface phenotype. They respond in an unconventional …