[HTML][HTML] Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation
E Le Poul, C Loison, S Struyf, JY Springael… - Journal of Biological …, 2003 - ASBMB
Short chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are produced at
high concentration by bacteria in the gut and subsequently released in the bloodstream.
Basal acetate concentrations in the blood (about 100 μm) can further increase to millimolar
concentrations following alcohol intake. It was known previously that SCFAs can activate
leukocytes, particularly neutrophils. In the present work, we have identified two previously
orphan G protein-coupled receptors, GPR41 and GPR43, as receptors for SCFAs …
high concentration by bacteria in the gut and subsequently released in the bloodstream.
Basal acetate concentrations in the blood (about 100 μm) can further increase to millimolar
concentrations following alcohol intake. It was known previously that SCFAs can activate
leukocytes, particularly neutrophils. In the present work, we have identified two previously
orphan G protein-coupled receptors, GPR41 and GPR43, as receptors for SCFAs …