Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice
S Kojima, A Asakawa, H Amitani, T Sakoguchi, N Ueno… - Peptides, 2009 - Elsevier
Long-term benefits of central leptin gene therapy in insulin-deficient diabetes are not known
despite its therapeutic effects in obesity animal models such as ob/ob and diet-induced
obese mice. Adult male mice were injected intraperitoneally with streptozotocin (STZ,
200mg/kg) to induce insulitis. A week later, only diabetic STZ-pretreated mice (blood
glucose> 350mg/dl) received intracerebroventricularly (icv) an injection of recombinant
adeno-associated virus vector (rAAV) encoding either green fluorescent protein (control), or …
despite its therapeutic effects in obesity animal models such as ob/ob and diet-induced
obese mice. Adult male mice were injected intraperitoneally with streptozotocin (STZ,
200mg/kg) to induce insulitis. A week later, only diabetic STZ-pretreated mice (blood
glucose> 350mg/dl) received intracerebroventricularly (icv) an injection of recombinant
adeno-associated virus vector (rAAV) encoding either green fluorescent protein (control), or …