Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice
N Ueno, A Inui, PS Kalra, SP Kalra - Peptides, 2006 - Elsevier
We have tested the hypothesis that sustained leptin action in the hypothalamus alone can
engender and maintain euglycemia in wild type mice and in two monogenic diabetic
models, the insulin-deficient nonobese Akita mice and the hyperinsulinemic leptin-deficient
obese, ob/ob mice. A single intracerebroventricular injection of recombinant adeno-
associated virus vector encoding leptin (rAAV-lep) enhanced leptin transgene expression in
the hypothalamus without any evidence of leptin leakage to the peripheral circulation, and …
engender and maintain euglycemia in wild type mice and in two monogenic diabetic
models, the insulin-deficient nonobese Akita mice and the hyperinsulinemic leptin-deficient
obese, ob/ob mice. A single intracerebroventricular injection of recombinant adeno-
associated virus vector encoding leptin (rAAV-lep) enhanced leptin transgene expression in
the hypothalamus without any evidence of leptin leakage to the peripheral circulation, and …