Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome)
are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and
hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover
during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by
age-related resistance to antilipotoxic protection by leptin.