[HTML][HTML] Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-κB-dependent XIAP up-regulation
MT Lin, CC Chang, ST Chen, HL Chang, JL Su… - Journal of Biological …, 2004 - ASBMB
The aggressiveness of a tumor is partly attributed to its resistance to chemotherapeutic
agent-induced apoptosis. Cysteine-rich 61 (Cyr61), from the CCN gene family, is a secreted
and matrix-associated protein, which is involved in many cellular activities such as growth
and differentiation. Here we established a cell model system to examine whether stable
expression of Cyr61 in MCF-7 cells can confer resistance to apoptosis and identify possible
participating mechanisms. We showed that stable cell lines overexpressing Cyr61 had …
agent-induced apoptosis. Cysteine-rich 61 (Cyr61), from the CCN gene family, is a secreted
and matrix-associated protein, which is involved in many cellular activities such as growth
and differentiation. Here we established a cell model system to examine whether stable
expression of Cyr61 in MCF-7 cells can confer resistance to apoptosis and identify possible
participating mechanisms. We showed that stable cell lines overexpressing Cyr61 had …