Aptamers: a new class of oligonucleotides in the drug discovery pipeline?
E Dausse, SDR Gomes, JJ Toulmé - Current opinion in pharmacology, 2009 - Elsevier
Aptamers are oligonucleotides identified in a randomly synthesized library containing up to
1015 different molecules that fold into defined three-dimensional structures. Following their
selection for predetermined properties at the end of an iterative process known as SELEX
(Systematic Evolution of Ligands by Exponential enrichment) they can be chemically
modified in order to provide them with additional properties. These molecules display both
high affinity and specificity for their target. Aptamers constitute promising molecules for …
1015 different molecules that fold into defined three-dimensional structures. Following their
selection for predetermined properties at the end of an iterative process known as SELEX
(Systematic Evolution of Ligands by Exponential enrichment) they can be chemically
modified in order to provide them with additional properties. These molecules display both
high affinity and specificity for their target. Aptamers constitute promising molecules for …