[HTML][HTML] The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis
P Gin, AY Hsu, SC Rothman, T Jonassen… - Journal of Biological …, 2003 - ASBMB
Coenzyme Q (Q) is a lipid that functions as an electron carrier in the mitochondrial
respiratory chain in eukaryotes. There are eight complementation groups of Q-deficient
Saccharomyces cerevisiae mutants, designated coq1–coq8. Here we have isolated the
COQ6 gene by functional complementation and, in contrast to a previous report, find it is not
an essential gene. coq6 mutants are unable to grow on nonfermentable carbon sources and
do not synthesize Q but instead accumulate the Q biosynthetic intermediate 3-hexaprenyl-4 …
respiratory chain in eukaryotes. There are eight complementation groups of Q-deficient
Saccharomyces cerevisiae mutants, designated coq1–coq8. Here we have isolated the
COQ6 gene by functional complementation and, in contrast to a previous report, find it is not
an essential gene. coq6 mutants are unable to grow on nonfermentable carbon sources and
do not synthesize Q but instead accumulate the Q biosynthetic intermediate 3-hexaprenyl-4 …