[HTML][HTML] Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin
E El-Hallous, T Sasaki, D Hubmacher, M Getie… - Journal of biological …, 2007 - ASBMB
Fibrillin-containing microfibrils in elastic and nonelastic extracellular matrices play important
structural and functional roles in various tissues, including blood vessels, lung, skin, and
bone. Microfibrils are supramolecular aggregates of several protein and nonprotein
components. Recently, a large region in the N-terminal portion of fibrillin-1 was
characterized as a multifunctional protein interaction site, including binding sites for fibulin-2
and-5 among others. Using a panel of recombinant fibrillin-1 swapped domain and deletion …
structural and functional roles in various tissues, including blood vessels, lung, skin, and
bone. Microfibrils are supramolecular aggregates of several protein and nonprotein
components. Recently, a large region in the N-terminal portion of fibrillin-1 was
characterized as a multifunctional protein interaction site, including binding sites for fibulin-2
and-5 among others. Using a panel of recombinant fibrillin-1 swapped domain and deletion …