Structure of the Mesothelin/MPF gene and characterization of its promoter
D Urwin, RA Lake - Molecular Cell Biology Research Communications, 2000 - Elsevier
Mesothelin is a cell-surface antigen of unknown function that is expressed in a highly tissue-
specific manner. Expression of the protein is limited to mesothelium, the tissue forming the
pleural, pericardial, and peritoneal membranes. The purpose of this study was to
characterize the gene and identify elements responsible for its transcription. The gene
contains an 1884-bp open reading frame encoded by 15 exons occupying 8 kb of human
chromosome 16. An 1850-bp region of genomic DNA at the 5′ end of the gene …
specific manner. Expression of the protein is limited to mesothelium, the tissue forming the
pleural, pericardial, and peritoneal membranes. The purpose of this study was to
characterize the gene and identify elements responsible for its transcription. The gene
contains an 1884-bp open reading frame encoded by 15 exons occupying 8 kb of human
chromosome 16. An 1850-bp region of genomic DNA at the 5′ end of the gene …