[HTML][HTML] G‐CSF‐mobilized peripheral blood mononuclear cells from diabetic patients augment neovascularization in ischemic limbs but with impaired capability
Background: Autologous transplantation of mobilized peripheral blood mononuclear cells (M‐
PBMNCs) is a novel approach to improve critical limb ischemia (CLI) in diabetes. However,
endothelial progenitor cells (EPCs) from diabetes are dysfunctional and impaired in
ischemia‐induced neovascularization. Objective: This study aimed to confirm the
compromised efficiency of diabetic M‐PBMNCs in therapeutic neovascularization, and to
determine the underlying mechanisms of this impairment. Methods: Diabetic M‐PBMNCs …
PBMNCs) is a novel approach to improve critical limb ischemia (CLI) in diabetes. However,
endothelial progenitor cells (EPCs) from diabetes are dysfunctional and impaired in
ischemia‐induced neovascularization. Objective: This study aimed to confirm the
compromised efficiency of diabetic M‐PBMNCs in therapeutic neovascularization, and to
determine the underlying mechanisms of this impairment. Methods: Diabetic M‐PBMNCs …