Probenecid pretreatment enhances anticonvulsant action of NBQX in mice
CP Taylor, MG Vartanian - European journal of pharmacology, 1992 - Elsevier
CP Taylor, MG Vartanian
European journal of pharmacology, 1992•ElsevierAbstract NBQX (2, 3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline) was studied
following intravenous administration to mice. Maximal electroshock seizures were
suppressed by low doses of NBQX (ED 50= 13 mg/kg) but effects had dissipated by 10 min
after a dose of 25 mg/kg. Coadministration of the transport inhibitor probenecid (-
dipropylsulphamoyl)-benzoic acid) enhanced and prolonged the anticonvulsant action of
NBQX and also enhanced and prolonged ataxia. NBQX may be rapidly eliminated by a …
following intravenous administration to mice. Maximal electroshock seizures were
suppressed by low doses of NBQX (ED 50= 13 mg/kg) but effects had dissipated by 10 min
after a dose of 25 mg/kg. Coadministration of the transport inhibitor probenecid (-
dipropylsulphamoyl)-benzoic acid) enhanced and prolonged the anticonvulsant action of
NBQX and also enhanced and prolonged ataxia. NBQX may be rapidly eliminated by a …
Abstract
NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline) was studied following intravenous administration to mice. Maximal electroshock seizures were suppressed by low doses of NBQX (ED50 = 13 mg/kg) but effects had dissipated by 10 min after a dose of 25 mg/kg. Coadministration of the transport inhibitor probenecid (-dipropylsulphamoyl)-benzoic acid) enhanced and prolonged the anticonvulsant action of NBQX and also enhanced and prolonged ataxia. NBQX may be rapidly eliminated by a process sensitive to probenecid.
Elsevier