[HTML][HTML] CD98-mediated links between amino acid transport and β1 integrin distribution in polarized columnar epithelia
In non-polarized cells, CD98 has been shown to both influence β 1 integrins and
heterodimerize with LAT-2, which confers amino acid transport capability on the LAT-
2/CD98 heterodimer. Since LAT-2 is most heavily expressed in intestine and CD98
associates with the β 1 integrin splice form selectively found in such epithelia, we
investigated the relationship and polarity of these proteins using the intestinal epithelial
model Caco2-BBE. CD98 was found to selectively coimmunoprecipitate with both LAT-2 and …
heterodimerize with LAT-2, which confers amino acid transport capability on the LAT-
2/CD98 heterodimer. Since LAT-2 is most heavily expressed in intestine and CD98
associates with the β 1 integrin splice form selectively found in such epithelia, we
investigated the relationship and polarity of these proteins using the intestinal epithelial
model Caco2-BBE. CD98 was found to selectively coimmunoprecipitate with both LAT-2 and …