Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models
R Shenkar, PN Venkatasubramanian, AM Wyrwicz… - …, 2008 - journals.lww.com
OBJECTIVE: We sought to assess the appearance of cerebral cavernous malformations
(CCM) on magnetic resonance imaging (MRI) scans in murine Ccm1 and Ccm2 gene
knockout models and to develop a technique of lesion localization for correlative
pathobiological studies METHODS: Brains from 18 CCM mutant mice (Ccm1+/− Trp53−/−
and Ccm2+/− Trp53−/−) and 28 control animals were imaged by gradient recalled echo
(T2*)-weighted MRI scans at 4.7-and 14.1-T in vivo and/or ex vivo. After MRI scanning, the …
(CCM) on magnetic resonance imaging (MRI) scans in murine Ccm1 and Ccm2 gene
knockout models and to develop a technique of lesion localization for correlative
pathobiological studies METHODS: Brains from 18 CCM mutant mice (Ccm1+/− Trp53−/−
and Ccm2+/− Trp53−/−) and 28 control animals were imaged by gradient recalled echo
(T2*)-weighted MRI scans at 4.7-and 14.1-T in vivo and/or ex vivo. After MRI scanning, the …