A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy.
K Rashid, CE Van der Zee, GM Ross… - Proceedings of the …, 1995 - National Acad Sciences
K Rashid, CE Van der Zee, GM Ross, CA Chapman, J Stanisz, RJ Riopelle, RJ Racine…
Proceedings of the National Academy of Sciences, 1995•National Acad SciencesKindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical
stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat
forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a
synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of
neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of
mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both …
stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat
forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a
synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of
neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of
mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both …
Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both kindling and kindling-induced synaptic reorganization.
National Acad Sciences